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Our primary goal is to understand how brain circuits control our sensations. Much of our work focuses on the neocortex and thalamus. These areas interest us because they are dynamic partners in the processing of neural signals essential for sensory perception, movement, and cognition. We aim to gain a holistic understanding of forebrain processing through studies at multiple scales: namely, the basic properties of individual neurons, their synapses, and the circuits they form with other neurons. Towards this goal, we use cutting-edge electrophysiological and optical tools both in vitro and in awake behaving preparations. Our findings should provide much-needed insight into how neural circuits in the human brain process sensory signals, and how they fail in disease.

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